Emerging roles of Notch signaling in the tumor microenvironment of digestive system cancers
Qingmiao Shi, Shuwen Yang, Leiya Fu, Chen Xue · 2026
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Description
Qingmiao Shi and co-authors review, in 2026, the Notch signalling pathway inside the tumour surroundings of digestive cancers. Notch is an old cell-to-cell communication system. Beyond driving tumour growth, it reshapes the neighbourhood that tumours live in. That reshaping helps cancers spread and resist treatment.
The review traces how faulty Notch activity recruits and steers immune cells. Suppressor cells, macrophages, neutrophils, and regulatory T cells all feature. Notch also activates fibroblasts, grows new vessels, and remodels the tissue scaffold. Together these effects build an immune-suppressing environment. The authors summarise Notch-blocking drugs and their pairing with immunotherapy and other targeted treatments. They argue better mapping of these roles could improve outcomes.
Catalog record
| CREATOR | Qingmiao Shi, Shuwen Yang, Leiya Fu, Chen Xue |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67114 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |