Unveiling natural anti-inflammatory compounds for sinusitis treatments by modulating FOXP3, C5aR1, and LIF
Chengjian Cao, Md Arefin Hossen, Md Sahriyer Efti, Ahmed A. Warda, Soad K. AlJaouni, Ali ElFar, Chaoxiang Lv · 2026
Read Unveiling natural anti-inflammatory compounds for sinusitis treatments by modulating FOXP3, C5aR1, and LIF by Chengjian Cao, Md Arefin Hossen, Md Sahriyer Efti, Ahmed A. Warda, Soad K. AlJaouni, Ali ElFar, Chaoxiang Lv (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13318746.txt.
Description
Chengjian Cao and co-authors review, in 2026, natural anti-inflammatory compounds for chronic rhinosinusitis. Current treatments calm downstream inflammation but miss the immune faults driving recurrence. The review centres on a regulatory axis of three players. They are FOXP3, the complement receptor C5aR1, and the factor LIF.
Literature from 2000 to 2026 across three databases was searched. In sinus disease with polyps, protective regulatory T cells are heavily depleted. Complement signalling through C5aR1 blocks new regulatory cells forming. LIF pushes the other way, raising FOXP3 and calming harmful responses. Compounds such as curcumin and rosmarinic acid act on these pathways. Bromelain and cineole already have clinical support in acute sinusitis.
Catalog record
| CREATOR | Chengjian Cao, Md Arefin Hossen, Md Sahriyer Efti, Ahmed A. Warda, Soad K. AlJaouni, Ali ElFar, Chaoxiang Lv |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61630 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |