Peritoneal metastasis in pancreatic cancer: molecular mechanisms, microenvironmental remodeling, and emerging intraperitoneal interventions
Junnan Chen, Kexin Li, Yuming Zou, Jinzu Yang, Lianjun Xing, Kunmin Xiao · 2026
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Description
Junnan Chen and colleagues review, in 2026, how pancreatic cancer spreads across the lining of the abdomen, a pattern that sharply worsens survival and quality of life. Their account follows the step-by-step route cancer cells take from the main tumour to new growths.
Key steps covered include cells breaking away, changing character, resisting death signals, escaping immune attack, sticking to the abdominal lining, and growing new blood vessels. Four linked drivers get special attention: altered energy use, tiny vesicles that carry messages between cells, stem-like cancer cells, and a reshaped immune setting. The review closes with treatments delivered inside the abdomen, in normal, heated, or pressurised forms, and their possible pairing with immunotherapy.
Catalog record
| CREATOR | Junnan Chen, Kexin Li, Yuming Zou, Jinzu Yang, Lianjun Xing, Kunmin Xiao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 94702 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |