Effects of metformin and exercise on Alzheimer's model induced by D-galactose in the rats: A behavioral, histological and BDNF gene study
Tahereh Varmazyar, Nasrin Heidariyeh, Shima Ababzadeh · 2026
Read Effects of metformin and exercise on Alzheimer's model induced by D-galactose in the rats: A behavioral, histological and BDNF gene study by Tahereh Varmazyar, Nasrin Heidariyeh, Shima Ababzadeh (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13318542.txt.
Description
Tahereh Varmazyar and co-authors report a 2026 rat study of metformin and exercise. They asked whether either treatment, or both together, protects memory. The disease model used D-galactose to mimic Alzheimer's disease. Animals were divided into eight groups for comparison.
Learning and movement were tested with a water maze and an open field. Brain tissue from the hippocampus was examined under the microscope. Expression of the BDNF gene was also measured. The combined group performed better on maze measures. Those rats received 100 mg/kg of metformin plus exercise. They showed less nerve cell damage than untreated model rats. Their BDNF expression was also higher. Movement did not differ, so the benefit centred on learning.
Catalog record
| CREATOR | Tahereh Varmazyar, Nasrin Heidariyeh, Shima Ababzadeh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46734 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |