Sleep Deprivation and Neuronal Hyperexcitation Share Transcriptomic Signatures
Markos Michail Chatzigiannis, Hideo Hagihara, Tsuyoshi Miyakawa · 2026
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Description
Markos Michail Chatzigiannis, Hideo Hagihara, and Tsuyoshi Miyakawa compare the gene signatures of sleep loss and overexcited neurons in this 2026 study. Sleep deprivation is tied to many mental disorders, yet its molecular footprint is unclear. Since long wakefulness raises brain firing, the team guessed the two states share a pattern.
They pooled dozens of public gene datasets from mouse brains and seizure models. Most comparisons showed strong overlap between the states, above all in samples taken soon after seizures. Shared genes covered plasticity, immune response, and inflammation pathways. The signal sat mainly in neurons and microglia, the brain's immune cells. The work frames sleep loss as a state close to acute overexcitation.
Catalog record
| CREATOR | Markos Michail Chatzigiannis, Hideo Hagihara, Tsuyoshi Miyakawa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |