PD-1 H (VISTA) drives immunosuppressive reprogramming of glioma-associated myeloid cells to promote glioma progression
Yuduo Guo, Chao Zhao, Huafeng Liu, Weihai Ning, Jitao Zhao, Yan Chen, Hang Li, Ying Li, Shengdian Wang, Hongwei Zhang · 2026
Read PD-1 H (VISTA) drives immunosuppressive reprogramming of glioma-associated myeloid cells to promote glioma progression by Yuduo Guo, Chao Zhao, Huafeng Liu, Weihai Ning, Jitao Zhao, Yan Chen, Hang Li, Ying Li, Shengdian Wang, Hongwei Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13317314.txt.
Description
Yuduo Guo and co-authors identify, in a 2026 study, an immune brake called PD-1H, or VISTA, that helps glioma brain tumors silence the body's defenses. The brake sits mostly on myeloid cells, the tumor's dominant immune population, rather than on the T cells most research targets.
Human tumor checks linked high brake levels with suppressive cell crowds, few killer T cells, more checkpoint molecules, and worse patient outcomes. In dishes, the brake pushed myeloid cells toward suppression and curbed killer T cell growth; in mice, it sped tumor growth. Blocking it with an antibody is now the therapeutic test the work sets up. The findings widen checkpoint therapy beyond its usual targets.
Catalog record
| CREATOR | Yuduo Guo, Chao Zhao, Huafeng Liu, Weihai Ning, Jitao Zhao, Yan Chen, Hang Li, Ying Li, Shengdian Wang, Hongwei Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44019 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |