Landiolol in perioperative and critical care: evidence, patient selection, and practical titration for targeted heart rate control: a narrative review
Cesare Biuzzi, Giulio Carinci, Lorenzo Sorelli, Benedetta Bidi, Chiara Albizzi, Daniele Marianello, Filippo Annoni, Federico Franchi, Gianluca Paternoster, Fabio Silvio Taccone, Sabino Scolletta · 2026
Read Landiolol in perioperative and critical care: evidence, patient selection, and practical titration for targeted heart rate control: a narrative review by Cesare Biuzzi, Giulio Carinci, Lorenzo Sorelli, Benedetta Bidi, Chiara Albizzi, Daniele Marianello, Filippo Annoni, Federico Franchi, Gianluca Paternoster, Fabio Silvio Taccone, Sabino Scolletta (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13317176.txt.
Description
Cesare Biuzzi and co-authors review a 2026 account of a fast heart drug used around surgery and in intensive care. The drug, landiolol, slows the heart rate and can be tuned minute by minute. It wears off fast once the drip stops. The review sums up trials and reports on who gains from it and how to dose it. Fast heart rhythms above the main chambers are a key use.
In those settings, the drug controlled rate well and was mostly well borne. In sepsis with a fast heart rate, it lowered rate without raising the need for other blood pressure drugs. Yet large trials have not shown clear gains in major outcomes such as survival. Guides do not back routine use for sepsis. The authors advise case-by-case use with close watch on blood flow.
Catalog record
| CREATOR | Cesare Biuzzi, Giulio Carinci, Lorenzo Sorelli, Benedetta Bidi, Chiara Albizzi, Daniele Marianello, Filippo Annoni, Federico Franchi, Gianluca Paternoster, Fabio Silvio Taccone, Sabino Scolletta |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |