Effective-Component Compatibility of Bufei Yishen Formula Alleviates Alveolar Epithelial Barrier Damage in COPD Through Inhibition of p38 MAPK Phosphorylation
Xuejie Shao, Lanxi Zhang, Mingyi Guo, Chen Wang, Haotian Chu, Yangqian Mo, Ruilong Lu, Peng Zhao, Yange Tian · 2026
Read Effective-Component Compatibility of Bufei Yishen Formula Alleviates Alveolar Epithelial Barrier Damage in COPD Through Inhibition of p38 MAPK Phosphorylation by Xuejie Shao, Lanxi Zhang, Mingyi Guo, Chen Wang, Haotian Chu, Yangqian Mo, Ruilong Lu, Peng Zhao, Yange Tian (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13316824.txt.
Description
Xuejie Shao and co-authors test, in a 2026 study, a refined herbal blend called ECC-BYF against the broken air sac barrier in COPD, the chronic lung disease where that barrier drives decline. The blend comes from the Bufei Yishen formula, a traditional prescription.
Rats made ill with smoke and repeated infection breathed and healed better on the blend, with tidier air sac cells and stronger barrier proteins. Lung wash fluid showed more of a calming signal and less of three inflammatory ones. In dish-grown lung cells, the blend likewise restored barrier proteins and blocked a key inflammatory switch, p38 MAPK; a compound that reopens that switch erased the benefit. The pathway anchors the formula's claim.
Catalog record
| CREATOR | Xuejie Shao, Lanxi Zhang, Mingyi Guo, Chen Wang, Haotian Chu, Yangqian Mo, Ruilong Lu, Peng Zhao, Yange Tian |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37303 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |