Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions and transcription start sites
Ludovica Monti, Genta Firth, Joana R Correia Faria, John M Kelly, Gem Flint, Silvia Galli, Thomas E Maher, Htay Mon Aye, Marco Di Antonio · 2026
Read Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions and transcription start sites by Ludovica Monti, Genta Firth, Joana R Correia Faria, John M Kelly, Gem Flint, Silvia Galli, Thomas E Maher, Htay Mon Aye, Marco Di Antonio (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13316426.txt.
Description
Ludovica Monti and her team, publishing in 2026, map folded DNA structures called G-quadruplexes across the genome of Trypanosoma brucei. That parasite causes African sleeping sickness. The folded structures, formed in guanine-rich stretches, may regulate genes, but where they sit in this species was largely unknown.
Computer analysis across 64 related species showed wide variation in how common these structures are. The team then produced the first chromatin-based genome-wide map in T. brucei, using antibody capture followed by sequencing. Structures clustered in coding regions and near where genes switch on and off, a pattern unlike human maps. A drug that locks the folds changed how genes carrying them behave, which backs a gene-control role and a possible treatment target.
Catalog record
| CREATOR | Ludovica Monti, Genta Firth, Joana R Correia Faria, John M Kelly, Gem Flint, Silvia Galli, Thomas E Maher, Htay Mon Aye, Marco Di Antonio |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 84 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |