Dysregulated glucagon signaling contributes to hypoglycemia after vertical sleeve gastrectomy in mice
Tyler M. Cook, Maigen Bethea, Silvania da Silva Teixeira, Carissa Birznieks, Andrew McClennan, Jasmine Hendrix, Richard KP Benninger, Mary-Elizabeth Patti, Darleen A. Sandoval · 2026
Read Dysregulated glucagon signaling contributes to hypoglycemia after vertical sleeve gastrectomy in mice by Tyler M. Cook, Maigen Bethea, Silvania da Silva Teixeira, Carissa Birznieks, Andrew McClennan, Jasmine Hendrix, Richard KP Benninger, Mary-Elizabeth Patti, Darleen A. Sandoval (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13316305.txt.
Description
Tyler M Cook and co-authors report 2026 mouse work on low blood sugar attacks that can follow sleeve surgery for weight loss. Their question centers on glucagon, the hormone that should raise blood sugar, and whether its release and effect go wrong after the operation.
Sleeved mice showed high glucagon after meals yet weak sugar gains from small glucagon doses, whether fed or fasted. In the fed state, a small dose even triggered insulin release and low sugar in some mice, an effect partly blocked by a drug that stops GLP-1 signaling. Islet cells taken out alone behaved mostly normally, which points to gut signals as the driver. The results reshape how doctors may think about treating these attacks.
Catalog record
| CREATOR | Tyler M. Cook, Maigen Bethea, Silvania da Silva Teixeira, Carissa Birznieks, Andrew McClennan, Jasmine Hendrix, Richard KP Benninger, Mary-Elizabeth Patti, Darleen A. Sandoval |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48213 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |