Application and challenges of chimeric antigen receptor T cell therapy in the treatment of acute myeloid leukemia (Review)
Jingjing Zhang, Feilin Wang, Dandan Sui, Ziyi Huang, Yijian Chen · 2026
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Description
Jingjing Zhang and colleagues wrote a 2026 review on engineered T cell treatment for acute myeloid leukemia, a fast-growing blood cancer with high relapse rates. The therapy, proven in some B cell cancers, faces special barriers in this disease, and the review maps both progress and roadblocks.
Unlike B cell cancers, this leukemia lacks targets found only on cancer cells, and tumors can shed targets, hide in a hostile local setting, and vary from cell to cell. The authors weigh fixes such as better target choice, redesigned receptor builds, and ways to soften the tumor setting. Their aim is a next round of cell products that last longer, hit more precisely, and help patients whose disease returned after standard care.
Catalog record
| CREATOR | Jingjing Zhang, Feilin Wang, Dandan Sui, Ziyi Huang, Yijian Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33343 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |