Systematic discovery of immunomodulatory plant-derived nanoparticles reveals RNA-mediated macrophage reprogramming
Dokyung Jung, Ju-Hyun Bae, Il-Young Jung, Na-Eun Kim, Jung Min Sung, Kyung-Won Doh, Minju Kim, Jiwoong Choi, Eunji Ha, Hee Jin Cho, Byung Sun Min, Jong Hyun Kim, Sin-Hyeog Im, Moon-Chang Baek · 2026
Read Systematic discovery of immunomodulatory plant-derived nanoparticles reveals RNA-mediated macrophage reprogramming by Dokyung Jung, Ju-Hyun Bae, Il-Young Jung, Na-Eun Kim, Jung Min Sung, Kyung-Won Doh, Minju Kim, Jiwoong Choi, Eunji Ha, Hee Jin Cho, Byung Sun Min, Jong Hyun Kim, Sin-Hyeog Im, Moon-Chang Baek (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13316234.txt.
Description
Dokyung Jung and a large team built a discovery platform in 2026 that screens plant-derived nanoparticles for immune effects in a systematic way, moving past the one-plant-at-a-time habit. They assembled a library of 110 nanoparticles from diverse plant groups, with full physical profiling and high-throughput function tests.
Particles from Allium tuberosum stood out, pushing macrophages toward an inflammatory state. Their power came mostly from inner RNA cargo, above all a microRNA that acts on the Bcl6 signaling axis to reprogram the cells. The particles also made cold tumors more sensitive to immune checkpoint therapy in tests.
Catalog record
| CREATOR | Dokyung Jung, Ju-Hyun Bae, Il-Young Jung, Na-Eun Kim, Jung Min Sung, Kyung-Won Doh, Minju Kim, Jiwoong Choi, Eunji Ha, Hee Jin Cho, Byung Sun Min, Jong Hyun Kim, Sin-Hyeog Im, Moon-Chang Baek |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76266 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |