R788 is Associated with Neuroprotective Effects in Experimental Ischemic Stroke Models via Modulation of the STAT1/Nrf2/GPX4 Axis
Yong Yang, Jing Wang, Heng Zhou, Cailei Jiang, Zhansheng Zhu, Yamei Wang · 2026
Read R788 is Associated with Neuroprotective Effects in Experimental Ischemic Stroke Models via Modulation of the STAT1/Nrf2/GPX4 Axis by Yong Yang, Jing Wang, Heng Zhou, Cailei Jiang, Zhansheng Zhu, Yamei Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13315857.txt.
Description
Yong Yang and co-authors report in 2026 that R788, a blocker of spleen tyrosine kinase, protects brain tissue in experimental ischemic stroke. Stroke is a leading cause of death and disability, and oxidative damage plus regulated cell death are key injury paths that treatment might target.
The team tested R788 in mice with a blocked middle cerebral artery and in nerve-like cells hurt by hydrogen peroxide, using 24 mice in four groups. Treated groups kept more living cells, with lower iron buildup and fat oxidation, and changes along the STAT1, Nrf2, and GPX4 axis. The results offer a new mechanism for stroke care ideas.
Catalog record
| CREATOR | Yong Yang, Jing Wang, Heng Zhou, Cailei Jiang, Zhansheng Zhu, Yamei Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57079 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |