Aptamer-based Salmonella enteritidis-inactivated vaccine injected intradermally elicits local leukocyte recruitment and mucosal immunity in broiler chickens
Santiago Uribe-Diaz, Abigeal I Omolewu, Jossie M Santamaria, Chrysta N Beck, Andressa Stein, Raul Marcon, Christine N Vuong, Gisela F Erf, Billy M Hargis, Young M Kwon · 2026
Read Aptamer-based Salmonella enteritidis-inactivated vaccine injected intradermally elicits local leukocyte recruitment and mucosal immunity in broiler chickens by Santiago Uribe-Diaz, Abigeal I Omolewu, Jossie M Santamaria, Chrysta N Beck, Andressa Stein, Raul Marcon, Christine N Vuong, Gisela F Erf, Billy M Hargis, Young M Kwon (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13315640.txt.
Description
Santiago Uribe-Diaz and co-authors tested a skin-delivered Salmonella vaccine in 2026 in broiler chickens. On-farm control of Salmonella Enteritidis needs vaccines that spark fast local defense and grow into lasting body-wide and gut protection. So the team used a killed vaccine boosted by a CD40-targeting DNA aptamer.
Thirty chicks were split into six small groups. They got salt solution, a chitosan-based vaccine, or the aptamer vaccine, given once into the skin or with an earlier under-skin prime and skin boost. Blood and cloacal swabs tracked specific IgY and IgA antibodies, and growing feather tissue showed local white cell recruitment after each dose.
Catalog record
| CREATOR | Santiago Uribe-Diaz, Abigeal I Omolewu, Jossie M Santamaria, Chrysta N Beck, Andressa Stein, Raul Marcon, Christine N Vuong, Gisela F Erf, Billy M Hargis, Young M Kwon |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51111 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |