Proteomics and human microchips identify Thrombospondin-1 as a potential biomarker for calciphylaxis stem cell therapy
Jiaying Hu, Shijiu Lu, Lianju Qin, Yaoting Sun, Xiaoxue Ye, Qinyi Lin, Jing Zhang, Ming Zeng, Jingjing Wu, Kang Liu, Jingfeng Zhu, Ling Zhang, Feng Chen, Zaozao Chen, Shihui Xu, Zhangzhi Xue, Yongwu Yu, Lu Li, Weigang Ge, Zhongze Gu, Cui Li, Zhonglan Su, Dan Luo, Shaowen Tang, Xinfang Tang, Wuziyi Ji, Anning Bian, Meihua Liao, Guicun Fang, Xiang Ma, Song Ning, Yugui Cui, Chunyan Jiang, Huimin Wu, Baiqiao Zhao, Xiuqin Wang, Ningxia Liang, Tingyu Xu, Jiayin Liu, Yun Liu · 2026
Read Proteomics and human microchips identify Thrombospondin-1 as a potential biomarker for calciphylaxis stem cell therapy by Jiaying Hu, Shijiu Lu, Lianju Qin, Yaoting Sun, Xiaoxue Ye, Qinyi Lin, Jing Zhang, Ming Zeng, Jingjing Wu, Kang Liu, Jingfeng Zhu, Ling Zhang, Feng Chen, Zaozao Chen, Shihui Xu, Zhangzhi Xue, Yongwu Yu, Lu Li, Weigang Ge, Zhongze Gu, Cui Li, Zhonglan Su, Dan Luo, Shaowen Tang, Xinfang Tang, Wuziyi Ji, Anning Bian, Meihua Liao, Guicun Fang, Xiang Ma, Song Ning, Yugui Cui, Chunyan Jiang, Huimin Wu, Baiqiao Zhao, Xiuqin Wang, Ningxia Liang, Tingyu Xu, Jiayin Liu, Yun Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13315452.txt.
Description
Jiaying Hu and a very large team searched blood proteins in 2026 for a marker of calciphylaxis. That is a rare and often fatal disease of kidney patients, where small vessels harden, clot, and kill skin. They compared patients with the disease and patients with uremia, before and after stem cell therapy from human amnion tissue.
Protein screens pointed to thrombospondin-1 as the top raised hub protein, and levels fell after stem cell treatment. Lab tests linked it and a TGF-beta binding protein to clotting and wound repair, and blocking related signals weakened serum-driven cell sticking and clotting. Confirmatory tests in a larger combined group supported the marker.
Catalog record
| CREATOR | Jiaying Hu, Shijiu Lu, Lianju Qin, Yaoting Sun, Xiaoxue Ye, Qinyi Lin, Jing Zhang, Ming Zeng, Jingjing Wu, Kang Liu, Jingfeng Zhu, Ling Zhang, Feng Chen, Zaozao Chen, Shihui Xu, Zhangzhi Xue, Yongwu Yu, Lu Li, Weigang Ge, Zhongze Gu, Cui Li, Zhonglan Su, Dan Luo, Shaowen Tang, Xinfang Tang, Wuziyi Ji, Anning Bian, Meihua Liao, Guicun Fang, Xiang Ma, Song Ning, Yugui Cui, Chunyan Jiang, Huimin Wu, Baiqiao Zhao, Xiuqin Wang, Ningxia Liang, Tingyu Xu, Jiayin Liu, Yun Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83138 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |