Genetic mutations governing ferroptosis sensitivity and resistance: a precision approach to cancer therapy
Peyman Tabnak, Mohammad Ebrahimnezhad, Zanyar HajiEsmailPoor · 2026
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Description
Peyman Tabnak, Mohammad Ebrahimnezhad, and Zanyar HajiEsmailPoor review in 2026 how gene changes shape a kind of cancer cell death called ferroptosis. In this death, iron drives fat damage until the cell breaks down. Many cancers have weak spots that this route could strike.
The review maps the main switches that turn the death on or off. It then traces how known cancer gene faults tilt cells toward or away from it, across lung, liver, breast, brain, and other cancers. Matching a drug to a tumor's gene faults could beat drug resistance. The authors link the death route to chemo and immune care.
Catalog record
| CREATOR | Peyman Tabnak, Mohammad Ebrahimnezhad, Zanyar HajiEsmailPoor |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 140 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |