Molecular engineering of Komagataella phaffii for venom toxin production
Francielle Almeida Cordeiro, Karla de Castro Figueiredo Bordon, Henrique Ranieri Covali-Pontes, Isabela Gobbo Ferreira, Gisele Adriano Wiezel, Isadora Lino Mendes, Malson Neilson de Lucena, Eliane Candiani Arantes · 2026
Read Molecular engineering of Komagataella phaffii for venom toxin production by Francielle Almeida Cordeiro, Karla de Castro Figueiredo Bordon, Henrique Ranieri Covali-Pontes, Isabela Gobbo Ferreira, Gisele Adriano Wiezel, Isadora Lino Mendes, Malson Neilson de Lucena, Eliane Candiani Arantes (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13315165.txt.
Description
Francielle Cordeiro and co-authors review how to manufacture animal venom toxins in an engineered yeast. Venom peptides are precise tools that drug developers prize as scaffolds, but milking venom gives tiny, variable yields. Making the toxins in microbes is the obvious route, yet these peptides are rich in sulfur crosslinks that must fold exactly, and hosts often chew them up or fail to secrete them. The yeast Komagataella phaffii offers eukaryotic folding machinery, strong promoters, and cheap dense fermentation.
The review analyzes what decides success in this host: promoters, secretion signals, folding, and process design. It compares yields across toxin families and names recurring bottlenecks. Engineering fixes are cataloged for each. The authors aim the guide at biotechnology teams scaling venom production, arguing that the yeast can turn exotic toxins from curiosities into manufacturable drug candidates. Careful strain design, they conclude, is where most gains remain.
Catalog record
| CREATOR | Francielle Almeida Cordeiro, Karla de Castro Figueiredo Bordon, Henrique Ranieri Covali-Pontes, Isabela Gobbo Ferreira, Gisele Adriano Wiezel, Isadora Lino Mendes, Malson Neilson de Lucena, Eliane Candiani Arantes |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |