Protocol for canalostomy in rats to enable inner ear injection
Lei Zhang, Hanwen Zhou, Wenjie Liu, Siyue Wang, Huiyue Wang, Jinyu Wang, Ning Cong, Jing Wang · 2026
Read Protocol for canalostomy in rats to enable inner ear injection by Lei Zhang, Hanwen Zhou, Wenjie Liu, Siyue Wang, Huiyue Wang, Jinyu Wang, Ning Cong, Jing Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13314900.txt.
Description
Lei Zhang and co-workers give a step-by-step surgical protocol for reaching the rat inner ear, published in 2026. Getting drugs or viruses into the inner ear is key for hearing and balance research. But the common rat routes are tight and risk harm to the ear bones or a key artery.
Their canalostomy method works through the mastoid bone: expose the bone, find the target semicircular canal, drill a small window, and inject measured doses. A fluorescence check then proves the dose landed where it should. The standard steps make delivery repeatable across labs, cutting the trial-and-error of older routes. Cleaner access should sharpen tests of gene and drug therapies for deafness and vertigo.
Catalog record
| CREATOR | Lei Zhang, Hanwen Zhou, Wenjie Liu, Siyue Wang, Huiyue Wang, Jinyu Wang, Ning Cong, Jing Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68752 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |