In vitro recapitulation of intramuscular mRNA vaccination with naive and recall antigens using a human lymphoid follicle chip platform
Yunhao Zhai, Min Wen Ku, Ka Yang, Aditya Patil, Pranav Prabhala, Liqun He, Yuncheng Man, Mizanur Rahman, Kavya Menon, Sven B. Spörri, Supriya Gharpure, Abdul Rahman Isaacs, Shay Ferdosi, Andrzej S. Pitek, Giulietta Maruggi, Sylvie Bertholet, Jessica Firestone, Kambiz Mousavi, Eric Miller, Kate Luisi, Caleb A. Hellman, LaTonya D. Williams, Georgia D. Tomaras, Peng Yin, Steven P. Gygi, Josie McAuliffe, Donald E. Ingber, Girija Goyal · 2026
Read In vitro recapitulation of intramuscular mRNA vaccination with naive and recall antigens using a human lymphoid follicle chip platform by Yunhao Zhai, Min Wen Ku, Ka Yang, Aditya Patil, Pranav Prabhala, Liqun He, Yuncheng Man, Mizanur Rahman, Kavya Menon, Sven B. Spörri, Supriya Gharpure, Abdul Rahman Isaacs, Shay Ferdosi, Andrzej S. Pitek, Giulietta Maruggi, Sylvie Bertholet, Jessica Firestone, Kambiz Mousavi, Eric Miller, Kate Luisi, Caleb A. Hellman, LaTonya D. Williams, Georgia D. Tomaras, Peng Yin, Steven P. Gygi, Josie McAuliffe, Donald E. Ingber, Girija Goyal (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13314794.txt.
Description
Yunhao Zhai and a large team build a lab model of mRNA vaccination on chips in their 2026 study. Guessing how well a new mRNA vaccine will work, and how toxic it may be, still leans on animal tests that often miss human responses.
Their setup doses human muscle cells and antigen-presenting cells with fat-bubble mRNA vaccines, mimicking a shot into muscle. Plain mRNA vaccines made antigen right in the presenting cells, while self-amplifying ones needed touch between muscle and presenting cells, as the authors report. Moving those cells and fluids to a lymphoid follicle chip, a tiny fluid device, mimicked drainage to lymph nodes. The chip follicles then grew and made fresh antibodies. The human tissue model may speed vaccine screening without animals.
Catalog record
| CREATOR | Yunhao Zhai, Min Wen Ku, Ka Yang, Aditya Patil, Pranav Prabhala, Liqun He, Yuncheng Man, Mizanur Rahman, Kavya Menon, Sven B. Spörri, Supriya Gharpure, Abdul Rahman Isaacs, Shay Ferdosi, Andrzej S. Pitek, Giulietta Maruggi, Sylvie Bertholet, Jessica Firestone, Kambiz Mousavi, Eric Miller, Kate Luisi, Caleb A. Hellman, LaTonya D. Williams, Georgia D. Tomaras, Peng Yin, Steven P. Gygi, Josie McAuliffe, Donald E. Ingber, Girija Goyal |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73369 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |