Effects of heart rate on cardiac function in normal mice and rats and in animal models of heart failure
Jiuli Zhao, Xiang Ji, Qing Xu, Shaojiao Liu, Sha Su, Yu Teng, Lei Wang, Mingjing Zhao · 2026
Read Effects of heart rate on cardiac function in normal mice and rats and in animal models of heart failure by Jiuli Zhao, Xiang Ji, Qing Xu, Shaojiao Liu, Sha Su, Yu Teng, Lei Wang, Mingjing Zhao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13314521.txt.
Description
Jiuli Zhao and colleagues test how heart rate skews heart function readings in small animals in their 2026 study. Ultrasound checks under anesthesia drive most rodent heart research, yet the rate itself can shift the numbers, blurring comparisons between healthy and failing hearts.
The team made heart failure in rats by tying a heart artery. The model group held 11 rats and the control group held 11 too, as counted in the report, and both were checked at days 7 and 28. Mice got a two-hit model of failure with kept ejection fraction, using a nitric oxide blocker plus a high-fat diet. By varying anesthesia depth, they set different heart rates and read function at each load. The aim was to name safe rate windows for fair measures, so labs can trust their ultrasound data.
Catalog record
| CREATOR | Jiuli Zhao, Xiang Ji, Qing Xu, Shaojiao Liu, Sha Su, Yu Teng, Lei Wang, Mingjing Zhao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55569 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |