TLR7/8 agonist 3M-052 formulated in micelles induces local type I IFN response and antiviral immunity in zebrafish larvae
Dean Porter, Hannah Wiggett, Axel Benchetrit, Pierre Boudinot, Bernard Verrier, Didier Gigmes, Thomas Trimaille, Jean-Pierre Levraud · 2026
Read TLR7/8 agonist 3M-052 formulated in micelles induces local type I IFN response and antiviral immunity in zebrafish larvae by Dean Porter, Hannah Wiggett, Axel Benchetrit, Pierre Boudinot, Bernard Verrier, Didier Gigmes, Thomas Trimaille, Jean-Pierre Levraud (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13314456.txt.
Description
Dean Porter and colleagues test a micelle-packed immune booster in zebrafish in their 2026 study. Tiny fat bubbles can carry adjuvant drugs to the right spot and spare the rest of the body, a prized trait for vaccine design.
The micelles held 3M-052, a drug that fires the TLR7 and TLR8 sensors. Glowing tagged micelles were shot into see-through zebrafish larvae, and the team watched where they went and which immune cells came, using live microscopy in reporter fish. Whole-body gene tests added a broad view of the response. The micelles cleared slowly from the shot site and drew in neutrophils and macrophages, signs of local immune firing, and a type I interferon response followed. Larvae were also infected with a tagged Sindbis virus to track antiviral effect. The fish model gives a fast read on adjuvant behavior.
Catalog record
| CREATOR | Dean Porter, Hannah Wiggett, Axel Benchetrit, Pierre Boudinot, Bernard Verrier, Didier Gigmes, Thomas Trimaille, Jean-Pierre Levraud |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36067 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |