Effectiveness and safety of probiotics in treating knee osteoarthritis: an updated systematic review and meta-analysis of randomized controlled trials
Keye Chen, Yan Sun, Longkang Cui, Yuchen Zhu, Bingbing Zhang, Lianguo Wu · 2026
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Description
Keye Chen and co-workers pool trials of probiotics for knee osteoarthritis in a 2026 review. This worn-joint disease is common in older adults, and a skewed gut microbe mix is now seen as part of its story, which makes live microbe therapy worth a hard look.
The team gathered randomized trials from Chinese and English databases and pooled pain scores, stiffness, function limits, and a blood inflammation marker. Probiotics showed no worse side effects than placebo and no grave safety flags, by the results reported. Gains looked best for two strains named in the report, Saccharomyces boulardii and a sakei strain called LB-P12. Yet the trials were few and small, which weakens the proof. The authors call for bigger trials before probiotics join standard knee care.
Catalog record
| CREATOR | Keye Chen, Yan Sun, Longkang Cui, Yuchen Zhu, Bingbing Zhang, Lianguo Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30630 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |