Preoperative gut microbiota depletion and metabolomic signatures predict postoperative pneumonia in patients with intracranial space-occupying lesions: a multi-omics prospective cohort study
Juan Chen, Zhiyu Li, Yewen Zhan, Qianqian Tan, Jin Li, Hong Pu · 2026
Read Preoperative gut microbiota depletion and metabolomic signatures predict postoperative pneumonia in patients with intracranial space-occupying lesions: a multi-omics prospective cohort study by Juan Chen, Zhiyu Li, Yewen Zhan, Qianqian Tan, Jin Li, Hong Pu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13314423.txt.
Description
Juan Chen and co-workers test whether gut signs before brain surgery can warn of lung infection after it, in a study of 2026. Patients with space-taking lesions in the skull often get pneumonia after surgery due to deep wounds, dulled awareness, and long bed rest.
The study enrolled 50 patients and took stool and blood samples before and after surgery. Gene sequencing tracked gut microbes, and mass spectrometry mapped body chemicals at large. Surgery lowered microbe variety in all patients, yet those who later got pneumonia started out with a clear lack of Roseburia, a gut bacterium, before surgery. Their blood also showed a state the authors call metabolic deficiency before the operation. The gut-lung link may give surgeons an early warning tool.
Catalog record
| CREATOR | Juan Chen, Zhiyu Li, Yewen Zhan, Qianqian Tan, Jin Li, Hong Pu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28478 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |