Magnesium oxide nanoparticles: A novel shield against CCl₄-induced hepatic damage via caspase-3 and TNF-α in rats
Harseen M. Rahim, Nadia A. Salih, Bruska Azhdar · 2026
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Description
Harseen M. Rahim, Nadia A. Salih, and Bruska Azhdar test, in a 2026 rat study, whether magnesium oxide nanoparticles can shield the liver from carbon tetrachloride, a liver poison that kills cells through inflammation and cell death. The twist is manufacturing. The team biosynthesized the particles from a plant extract at two acidity levels, pH 5 and pH 9. They gave them to rats across six groups, with and without the toxin, and scored two damage markers in liver tissue.
The toxin alone drove both markers to their scores, ten and twelve on the team's scale, against zero in healthy controls. Nanoparticles pushed the scores down, and the alkaline-made batch worked better. Its group scored four on the cell-death marker and two on the inflammation marker, against six and six for the acid-made batch. The authors conclude that synthesis conditions tune protective power, a variable nanoparticle medicine often ignores.
Catalog record
| CREATOR | Harseen M. Rahim, Nadia A. Salih, Bruska Azhdar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |