GRN rs5848 variant associates with TDP-43 pathology and cancer in opposite directions
Khine Zin Aung, Peter T Nelson, Xiaotong Ning, Xian Wu, Inori Tsuchiya, Shama Karanth, Erin L Abner, David W Fardo, Yuriko Katsumata · 2026
Read GRN rs5848 variant associates with TDP-43 pathology and cancer in opposite directions by Khine Zin Aung, Peter T Nelson, Xiaotong Ning, Xian Wu, Inori Tsuchiya, Shama Karanth, Erin L Abner, David W Fardo, Yuriko Katsumata (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13314055.txt.
Description
Khine Zin Aung and eight co-authors test a gene variant that links brain protein buildup and cancer in opposite ways, in a study from 2026. Cancer survivors seem to develop dementia less often, for reasons still unclear. One gene lowers a growth protein when a common variant is present, which raises brain pathology risk.
Using gene data from two large Alzheimer consortia and pathology records from a national center, they found the variant raised odds of a specific age-related brain change and of hippocampal scarring. The same variant lowered odds of cancer. Other Alzheimer risk variants showed no cancer link, which argues against simple sample bias.
Catalog record
| CREATOR | Khine Zin Aung, Peter T Nelson, Xiaotong Ning, Xian Wu, Inori Tsuchiya, Shama Karanth, Erin L Abner, David W Fardo, Yuriko Katsumata |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |