Different dose-based multi HN&F epitope mRNA vaccine against Newcastle disease
Asma Abdlhusen Shrshoh, Nafea Sabih Jasim · 2026
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Description
Asma Abdlhusen Shrshoh and Nafea Sabih Jasim report, in a 2026 study, the design and trial of a multi-epitope mRNA vaccine against Newcastle disease, a scourge of poultry farming. Rather than using whole virus, the vaccine stitches together predicted immune-triggering fragments from the virus's two proteins. They were selected for binding strength, antigenicity, safety, and conservation across strains. Two hundred eighty chickens were randomized into eight groups, including the vaccine, six commercial vaccines, and an unvaccinated control, then challenged with a virulent strain.
Birds receiving the mRNA vaccine mounted higher antibody titers than controls, with stronger lymphocyte proliferation and more interferon-producing cells. After challenge, that group showed the best protection, with the fewest and mildest clinical signs and the lowest mortality. It edged out rival products. The authors claim a first for this vaccine architecture against Newcastle disease. They argue such mRNA designs could modernize poultry vaccination.
Catalog record
| CREATOR | Asma Abdlhusen Shrshoh, Nafea Sabih Jasim |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |