Decoding antidengue serotype-3 (DENV-3) mechanism of natural glycosides from Alpinia purpurata: Molecular docking and in vitro insights into viral entry, cytokine storm modulation, and endogenous antioxidant defense activation
Mochammad Aqilah Herdiansyah, Win Darmanto, Dwi Winarni, Aulia Umi Rohmatika, Rr Aulia Rahmawati Kusuma Putri, Raden Joko Kuncoroningrat Susilo, Teguh Hari Sucipto, Putu Angga Wiradana, Farach Khanifah, Ernawati Ernawati · 2026
Read Decoding antidengue serotype-3 (DENV-3) mechanism of natural glycosides from Alpinia purpurata: Molecular docking and in vitro insights into viral entry, cytokine storm modulation, and endogenous antioxidant defense activation by Mochammad Aqilah Herdiansyah, Win Darmanto, Dwi Winarni, Aulia Umi Rohmatika, Rr Aulia Rahmawati Kusuma Putri, Raden Joko Kuncoroningrat Susilo, Teguh Hari Sucipto, Putu Angga Wiradana, Farach Khanifah, Ernawati Ernawati (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13313891.txt.
Description
Mochammad Aqilah Herdiansyah and co-authors explore, in a 2026 study, whether natural compounds from red galangal can fight dengue virus serotype 3, for which no specific antiviral drug exists. The rhizome of Alpinia purpurata is rich in glycosides with antioxidant reputations. The team tested the extracts against the virus in cell culture. They used molecular docking and dynamics simulations to see how the compounds might block viral entry and calm the cytokine storm.
One compound, quercetin-3-O-rutinoside, outperformed the quercetin control at every target tested. It bound the viral entry receptor most tightly, at minus 7.8 kilocalories per mole in the docking scores. Cell experiments confirmed inhibition of viral replication, and screening predicted the compound to be cell-safe with workable drug-like properties. The authors claim the first combined wet-lab and computer evidence for this plant as a source of antidengue candidates.
Catalog record
| CREATOR | Mochammad Aqilah Herdiansyah, Win Darmanto, Dwi Winarni, Aulia Umi Rohmatika, Rr Aulia Rahmawati Kusuma Putri, Raden Joko Kuncoroningrat Susilo, Teguh Hari Sucipto, Putu Angga Wiradana, Farach Khanifah, Ernawati Ernawati |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |