Development and characterization of triazole-based WDR5 inhibitors for the treatment of glioblastoma
Jesse A Coker, Steven R Martinez, Sang Hoon Han, Anthony R Sloan, Amit Kumar Gupta, George Bukenya, Paul Polzer, James H Ramos, Emma G Rico, Annabella Rico, A Abigail Lindsey, Tanvi Navadgi, Natalie Reitz, Todd Romigh, Jonathan Macdonald, Dhiraj Sonawane, Christopher M Goins, Christopher G Hubert, N · 2026
Read Development and characterization of triazole-based WDR5 inhibitors for the treatment of glioblastoma by Jesse A Coker, Steven R Martinez, Sang Hoon Han, Anthony R Sloan, Amit Kumar Gupta, George Bukenya, Paul Polzer, James H Ramos, Emma G Rico, Annabella Rico, A Abigail Lindsey, Tanvi Navadgi, Natalie Reitz, Todd Romigh, Jonathan Macdonald, Dhiraj Sonawane, Christopher M Goins, Christopher G Hubert, N (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13313556.txt.
Description
Jesse Coker, Steven Martinez, Sang Hoon Han, and a wider team wrote this research paper, published in 2026. It develops drugs that block WDR5, a scaffold protein that brain cancer stem cells depend on, designed to reach the brain where older blockers could not.
Glioblastoma returns because its stem cells resist treatment. WDR5 helps those cells run their gene programs, making it a tempting target. Past blockers crossed the blood-brain barrier poorly. The team's new series, built around triazole rings, was shaped to slip into the brain passively. The compounds proved potent and, in some cases, more brain-penetrant than rival designs. Tests in patient-derived stem cell models showed slowed growth, in dishes and in animals. A screen of two thousand probe compounds found a partner drug that sharply boosts the killing.
Catalog record
| CREATOR | Jesse A Coker, Steven R Martinez, Sang Hoon Han, Anthony R Sloan, Amit Kumar Gupta, George Bukenya, Paul Polzer, James H Ramos, Emma G Rico, Annabella Rico, A Abigail Lindsey, Tanvi Navadgi, Natalie Reitz, Todd Romigh, Jonathan Macdonald, Dhiraj Sonawane, Christopher M Goins, Christopher G Hubert, N |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |