FOXC2 and WT1 regulate transcriptional reprogramming during the podocyte response to injury
Sandrine Ettou, Anya Greenberg, Sangyoon Lee, Arjun Rajesh, Liang Sun, Nahid Tabibzadeh, Haruka Oishi, Ran Konoe, Phillip J. McCown, Sean Eddy, Victoria Driscoll, Tomoya Miyoshi, Ken Hiratsuka, Jason Lam, R. Sathish Srinivasan, Youngsook L. Jung, Biju Isaac, Mingwei Sun, Mary E. Taglienti, Keith Kel · 2026
Read FOXC2 and WT1 regulate transcriptional reprogramming during the podocyte response to injury by Sandrine Ettou, Anya Greenberg, Sangyoon Lee, Arjun Rajesh, Liang Sun, Nahid Tabibzadeh, Haruka Oishi, Ran Konoe, Phillip J. McCown, Sean Eddy, Victoria Driscoll, Tomoya Miyoshi, Ken Hiratsuka, Jason Lam, R. Sathish Srinivasan, Youngsook L. Jung, Biju Isaac, Mingwei Sun, Mary E. Taglienti, Keith Kel (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13313500.txt.
Description
Sandrine Ettou and a team investigate, in a 2026 study, how two transcription factors choreograph the podocyte's response to injury. Podocytes are the kidney's filter-guarding cells, and their damage opens the road to chronic kidney disease. Both FOXC2 and WT1 maintain the filter in health. Their teamwork during injury, though, was unmapped. Using mouse models of podocyte injury, binding maps, and mice lacking each factor in podocytes, the researchers followed the pair over time.
Binding proved dynamic. FOXC2's grip on its target genes first tightened early in injury, then collapsed late as its levels fell sharply. Removing either factor in podocytes blunted the transcriptional response, showing both are required to mount it. The two factors also shared many of the same gene targets. The picture is of a coordinated, time-varying repair program. Its failure points may explain why injured filters scar instead of heal.
Catalog record
| CREATOR | Sandrine Ettou, Anya Greenberg, Sangyoon Lee, Arjun Rajesh, Liang Sun, Nahid Tabibzadeh, Haruka Oishi, Ran Konoe, Phillip J. McCown, Sean Eddy, Victoria Driscoll, Tomoya Miyoshi, Ken Hiratsuka, Jason Lam, R. Sathish Srinivasan, Youngsook L. Jung, Biju Isaac, Mingwei Sun, Mary E. Taglienti, Keith Kel |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |