Rescuing age-associated vaccine hyporesponsiveness in murine and nonhuman primate models with an immunostimulatory vaccine adjuvant
Jill Maxwell, Jason A Joyner, James E Norton, Walter Knapp, I-Ming Wang, Gokul Swaminathan, Morgan A Monslow, Michael P Citron · 2026
Read Rescuing age-associated vaccine hyporesponsiveness in murine and nonhuman primate models with an immunostimulatory vaccine adjuvant by Jill Maxwell, Jason A Joyner, James E Norton, Walter Knapp, I-Ming Wang, Gokul Swaminathan, Morgan A Monslow, Michael P Citron (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13313280.txt.
Description
Jill Maxwell and co-workers show in a 2026 study that a strong vaccine adjuvant can rescue weak vaccine responses in old animals. Aging dulls the immune system, a change called immunosenescence, and older people often gain less from shots even though they need them most.
The team compared vaccine types in aged mice and then in monkeys, setting each against young animals. The chief age mark was lower antibody output after shots given into the body. Adding a proven immune-boosting adjuvant, one with a record of working in people, reversed that low output in both animal types. The result offers a clear path to better shots for older adults: pair the vaccine with a strong helper rather than accept weak responses as fixed.
Catalog record
| CREATOR | Jill Maxwell, Jason A Joyner, James E Norton, Walter Knapp, I-Ming Wang, Gokul Swaminathan, Morgan A Monslow, Michael P Citron |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46912 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |