Targeting a conserved flagellin D1 epitope with 16G10 confers cross-serotype protection in murine Pseudomonas aeruginosa infection models
Ying Wang, Yating Wang, Zifan Zhu, Qian Wang, Xinglong Liu, Qingli Cai, Yueyue Zhang, Yuhang Li, Hui Zhao, Xin Cheng, Jiang Gu, Quanming Zou, Jianxin Jiang · 2026
Read Targeting a conserved flagellin D1 epitope with 16G10 confers cross-serotype protection in murine Pseudomonas aeruginosa infection models by Ying Wang, Yating Wang, Zifan Zhu, Qian Wang, Xinglong Liu, Qingli Cai, Yueyue Zhang, Yuhang Li, Hui Zhao, Xin Cheng, Jiang Gu, Quanming Zou, Jianxin Jiang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13313250.txt.
Description
Ying Wang and a large team report a 2026 antibody study aimed at Pseudomonas aeruginosa, a germ that more and more often shrugs off antibiotics. They sought a treatment that works no matter the drug resistance, by aiming at flagellin, the protein of the tail the germ swims with.
From a panel of 20 antibodies against flagellin FliC, they picked 16G10 as the lead for its strong binding. Mapping showed it grips a short stretch in the D1 domain, from Gly71 to Ile88, a site kept across types and key to building the tail. In lab tests the antibody clumped the germs, slowed swimming, cut entry into lung cells, and shrank biofilms. In mouse lung infection, even against a drug-proof strain, it raised survival, lowered germ counts, and calmed inflammation.
Catalog record
| CREATOR | Ying Wang, Yating Wang, Zifan Zhu, Qian Wang, Xinglong Liu, Qingli Cai, Yueyue Zhang, Yuhang Li, Hui Zhao, Xin Cheng, Jiang Gu, Quanming Zou, Jianxin Jiang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39527 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |