The dual role of leukotrienes in the tumor microenvironment: balancing pro-tumorigenic and anti-tumor immunity
Andrew Thake, Maria Caruso, Sebastian Fernandez-Bussy, Keith Sacco · 2026
Read The dual role of leukotrienes in the tumor microenvironment: balancing pro-tumorigenic and anti-tumor immunity by Andrew Thake, Maria Caruso, Sebastian Fernandez-Bussy, Keith Sacco (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13313223.txt.
Description
Andrew Thake and co-authors review leukotrienes, fat-based signals made through the 5-lipoxygenase path, and their two-sided role in cancer in a paper from 2026. These signals shape inflammation around a tumor and touch vessel growth, immune action, and the spread of cancer to new sites.
The review weighs lab, clinical, and population studies chosen by set rules, with weight on recent work. Signals through this path track with markers such as the CysLT1 receptor, beta-catenin activity, and HIF-1 alpha signals. In lab models, drugs such as montelukast and zileuton and blockers of the FLAP protein slowed tumor growth and restored cell death, while human proof so far rests mostly on observed data. The authors argue for trials that pick patients by markers, so the path can be targeted where it matters most.
Catalog record
| CREATOR | Andrew Thake, Maria Caruso, Sebastian Fernandez-Bussy, Keith Sacco |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37850 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |