Biological consequences of Z-nucleic acid sensing by ZBP1 and ADAR1
Fei Lu, Linghuan Tang, Chun Kim, Dengming Lai, Jinfa Tou, Huipeng Jiao · 2026
Read Biological consequences of Z-nucleic acid sensing by ZBP1 and ADAR1 by Fei Lu, Linghuan Tang, Chun Kim, Dengming Lai, Jinfa Tou, Huipeng Jiao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13313186.txt.
Description
Fei Lu and fellow authors review Z-nucleic acids, rare forms of DNA and RNA that twist to the left instead of the right, in their 2026 paper. Two proteins with Z-binding parts, ZBP1 and ADAR1, sense these odd shapes, and their roles in health and disease have long been a puzzle.
The review draws on mouse genetics, using knockout mice and mice with changed Z-binding sites, to show what these sensors do. The evidence casts Z-nucleic acids as key triggers of planned cell death, swelling, defense against viruses, and attacks on tumors. That same sensing can also drive diseases of excess inflammation. By weighing both sides, the review helps readers see when blocking or boosting this system might help patients.
Catalog record
| CREATOR | Fei Lu, Linghuan Tang, Chun Kim, Dengming Lai, Jinfa Tou, Huipeng Jiao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58884 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |