Rarely reported cases of hepatotoxicity associated with turmeric- and curcuminoid-containing dietary supplements: a comprehensive review by USP
Nadeem Akhtar, Joanne Barnes, Paula Gardiner, Bill J. Gurley, Richard Ko, Igor Koturbash, Deval Patel, Richard B. van Breemen, Amy L. Roe · 2026
Read Rarely reported cases of hepatotoxicity associated with turmeric- and curcuminoid-containing dietary supplements: a comprehensive review by USP by Nadeem Akhtar, Joanne Barnes, Paula Gardiner, Bill J. Gurley, Richard Ko, Igor Koturbash, Deval Patel, Richard B. van Breemen, Amy L. Roe (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13312837.txt.
Description
Nadeem Akhtar and fellow members of a United States Pharmacopeia expert committee report a 2026 safety review of turmeric and curcuminoid supplements after scattered reports of liver injury. The committee routinely watches the literature for ingredients in USP monographs and launched a full evaluation to decide whether turmeric products need a caution on their labels.
Animal studies showed liver harm only at high doses of powder or extract, and the many human trials of these supplements reported no organ toxicity or serious events. Published injury cases usually appeared after one to four months of use, often alongside other medicines, and they generally cleared once the supplement stopped. Rare liver failure has occurred, though. The committee recommends a cautionary label advising people with liver history to consult a practitioner and to stop and seek care if symptoms such as jaundice appear.
Catalog record
| CREATOR | Nadeem Akhtar, Joanne Barnes, Paula Gardiner, Bill J. Gurley, Richard Ko, Igor Koturbash, Deval Patel, Richard B. van Breemen, Amy L. Roe |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 116940 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |