Protective effect of Caftaric Acid against hepatic cold ischemia/reperfusion injury in the liver
Ying Zhu, Hao Li, Minghao Li, Wenzheng Ruan, Mingjie Ding, Guohua You, Lele Zhang, Wenzhi Guo · 2026
Read Protective effect of Caftaric Acid against hepatic cold ischemia/reperfusion injury in the liver by Ying Zhu, Hao Li, Minghao Li, Wenzheng Ruan, Mingjie Ding, Guohua You, Lele Zhang, Wenzhi Guo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13312766.txt.
Description
Ying Zhu and seven colleagues test a grape-related acid for protecting the liver during transplant storage, in a paper dated twenty twenty-six. Livers held cold before transplant get hurt when blood returns, which can make the graft fail early. The acid, caftaric acid, rises in hibernating animals that adapt to cold. The team tested it on liver tissue under cold storage and blood return.
The acid cut dead tissue area, eased cell suicide, and restored the liver's chemical balance. Gene reads pointed to a stress pathway, and tests showed the acid binds directly to a key switch in it, JNK1. By tuning that pathway, the acid lowered cell stress and damage. It may become a drug to guard stored livers.
Catalog record
| CREATOR | Ying Zhu, Hao Li, Minghao Li, Wenzheng Ruan, Mingjie Ding, Guohua You, Lele Zhang, Wenzhi Guo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |