Trial trustworthiness assessment: commentary on the Cochrane 2025 systematic review on calcium supplementation during pregnancy
Maria Regina Torloni, Gabriela Cormick, Alvaro Nagib Atallah · 2026
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Description
Maria Regina Torloni and co-authors write a 2026 commentary challenging the trustworthiness judgments behind the 2025 Cochrane review of calcium supplements in pregnancy. Calcium is recommended worldwide to prevent preeclampsia, largely on earlier versions of that review. The update concluded the supplement may do little or nothing, a reversal driven mainly by dropping trials judged untrustworthy.
The authors argue the criteria were read and applied unevenly across trials, showing through two examples how worries about ethics approval and effect size counted against some studies but not others. The same trials passed as trustworthy in a sister Cochrane review updated in 2024, and sensitivity checks show that restoring the two examples would shift the pooled preeclampsia estimate significantly. They urge a reassessment of every excluded trial and warn that unvalidated trustworthiness tools can bend guidelines.
Catalog record
| CREATOR | Maria Regina Torloni, Gabriela Cormick, Alvaro Nagib Atallah |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 18231 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |