Decoding GPCR signaling reprogramming in cancer: molecular mechanisms and therapeutic implications
Shorouk Aldeyarbi, Marwan El-Deyarbi, Ashraf A. Hussein, Zelal S. Adi, Salahdein Aburuz · 2026
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Description
Shorouk Aldeyarbi and co-authors review how a large family of cell receptors is rewired in cancer, in a review from 2026. These receptors, called GPCRs, are the largest receptor family in the human genome. They steer cell signals that keep the body in balance and shape drug response.
The review maps the main signal chains these receptors drive, and how each can push tumor growth, survival, and spread. Changes at gene, control, and protein levels all play a part. Some drugs that target these receptors, such as SMO and chemokine receptor blockers, already show promise in cancer care. The authors also cover imaging uses and pairing strategies, aiming to link basic biology with clinic work.
Catalog record
| CREATOR | Shorouk Aldeyarbi, Marwan El-Deyarbi, Ashraf A. Hussein, Zelal S. Adi, Salahdein Aburuz |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 108 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |