Exploring differences in protein cargo of extracellular vesicles from ME/CFS patient plasma compared to healthy controls
Anne Rydland, Elena Støvring Yran, Tuula A. Nyman, Elin Bolle Strand, Anne-Marie Siebke Trøseid, Reidun Øvstebø, Fatima Heinicke, Benedicte A. Lie, Marte K. Viken · 2026
Read Exploring differences in protein cargo of extracellular vesicles from ME/CFS patient plasma compared to healthy controls by Anne Rydland, Elena Støvring Yran, Tuula A. Nyman, Elin Bolle Strand, Anne-Marie Siebke Trøseid, Reidun Øvstebø, Fatima Heinicke, Benedicte A. Lie, Marte K. Viken (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13312568.txt.
Description
Anne Rydland and co-authors explore, in a 2026 study, whether the protein cargo of tiny cell-made particles in blood differs in people with ME/CFS. This exhausting chronic illness, marked by crashes after exertion, pain, and deep fatigue, still lacks a known mechanism. Extracellular vesicles, which ferry signals between cells, might carry a readable trace of it.
The team enriched vesicles from the plasma of 49 patients and 50 healthy controls and measured their proteins with high-resolution proteomics. Patients carried significantly higher vesicle concentrations. Of 424 proteins analyzed, 11 differed between groups, mostly tracing back to red blood cell, liver, and plasma B cell origins. None of the differences survived strict correction for multiple testing, though. As the largest such study so far, the authors present it as encouragement for deeper work on vesicles in this disease.
Catalog record
| CREATOR | Anne Rydland, Elena Støvring Yran, Tuula A. Nyman, Elin Bolle Strand, Anne-Marie Siebke Trøseid, Reidun Øvstebø, Fatima Heinicke, Benedicte A. Lie, Marte K. Viken |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33380 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |