Spatial associations between neuronal membrane damage and vasculature after repetitive diffuse TBI in pigs
Kathryn L. Wofford, Erin M. Purvis Conway, Victor P. Acero, Jerry Gao, Olivia M. Rivellini, Emory Kuo, Constance J. Mietus, Kevin D. Browne, John C. O’Donnell, D. Kacy Cullen · 2026
Read Spatial associations between neuronal membrane damage and vasculature after repetitive diffuse TBI in pigs by Kathryn L. Wofford, Erin M. Purvis Conway, Victor P. Acero, Jerry Gao, Olivia M. Rivellini, Emory Kuo, Constance J. Mietus, Kevin D. Browne, John C. O’Donnell, D. Kacy Cullen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13312530.txt.
Description
Kathryn Wofford and co-authors map where nerve cell membranes tear after repeated head impacts in pigs, and whether blood vessels mark the danger zones. Closed-head brain injury scatters its damage widely, but what sets the micro-scale pattern was unknown. Because vessels differ mechanically from the soft tissue around them, the team guessed damage would cluster near vessels.
Using a pig model of rotational head injury, they counted permeabilized neurons, cells whose membranes leaked, across brain regions. A single rotation raised the share of regions containing damaged neurons in cortex, thalamus, and midbrain. After repeated injury, the midbrain held more damaged neurons and fewer large vessels. Careful mapping showed damaged neurons packed more densely near vessels, though vessel size itself did not matter.
Catalog record
| CREATOR | Kathryn L. Wofford, Erin M. Purvis Conway, Victor P. Acero, Jerry Gao, Olivia M. Rivellini, Emory Kuo, Constance J. Mietus, Kevin D. Browne, John C. O’Donnell, D. Kacy Cullen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |