DCAF7 enhances atherosclerosis in vascular endothelial cells by promoting SLC40A1 transcription through facilitating TNF-mediated NF-κB function
Sien Guo, Peng Yan, Gengchen Niu, Biqi Li, Ni Wu, Qisen Yao, Shengyuan Wang, Chongyuan Hu, Yisheng Zheng, Yihe Yan, Huafu Li, Chunming Wang · 2026
Read DCAF7 enhances atherosclerosis in vascular endothelial cells by promoting SLC40A1 transcription through facilitating TNF-mediated NF-κB function by Sien Guo, Peng Yan, Gengchen Niu, Biqi Li, Ni Wu, Qisen Yao, Shengyuan Wang, Chongyuan Hu, Yisheng Zheng, Yihe Yan, Huafu Li, Chunming Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13311996.txt.
Description
Sien Guo and colleagues, in 2026, present a study on a protein called DCAF7 that speeds artery plaque growth in vessel lining cells. Dataset mining first flagged cell death as a key thread in atherosclerosis.
The iron-linked death factor SLC40A1 ran high in diseased vessels, and DCAF7 seemed to drive it. Cell and animal tests showed DCAF7 lifts SLC40A1 by way of TNF and NF-kappaB signaling, promoting cell death. In mice lacking ApoE, silencing DCAF7 slowed carotid plaque growth and cut cell death clearly. The authors name DCAF7 a candidate target for halting plaque progression.
Catalog record
| CREATOR | Sien Guo, Peng Yan, Gengchen Niu, Biqi Li, Ni Wu, Qisen Yao, Shengyuan Wang, Chongyuan Hu, Yisheng Zheng, Yihe Yan, Huafu Li, Chunming Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38310 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |