UK participation in the UK National External Quality Assessment Scheme for mismatch repair immunohistochemistry: insights from the last decade
Luke AR Farmkiss, Andrew Dodson, Suzanne Parry, Michelle Charmaine James, Ian M Frayling, Mark Johan Arends · 2026
Read UK participation in the UK National External Quality Assessment Scheme for mismatch repair immunohistochemistry: insights from the last decade by Luke AR Farmkiss, Andrew Dodson, Suzanne Parry, Michelle Charmaine James, Ian M Frayling, Mark Johan Arends (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13311966.txt.
Description
Luke AR Farmkiss and colleagues, in 2026, analyze a decade of British quality assessment data for mismatch repair protein staining in tumors. The stain guides Lynch syndrome detection, variant reading, and immunotherapy choices.
Between 2011 and 2022 the scheme ran 38 assessment rounds, averaging about 45 submissions per antigen per round. Participation grew steeply over the decade. Average scores edged up slightly, with tighter agreement in the second half. The report names the best-scoring antibody clones for each of the four proteins, MLH1, MSH2, MSH6, and PMS2. Labs can use the rankings to pick reagents that stain most reliably.
Catalog record
| CREATOR | Luke AR Farmkiss, Andrew Dodson, Suzanne Parry, Michelle Charmaine James, Ian M Frayling, Mark Johan Arends |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30997 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |