A LECT2-eluting in situ coaxial electrospun nanofiber dressing orchestrates oxidative stress resolution and immune reprogramming for accelerated wound healing
Zhichao Zheng, Jiasheng Mao, Haohui Zhu, Zhihe Fu, Wei Xie, Shaofen Xu, Yan Wang, Shuiqing Yu, Ziyi Liu, Lijing Wang, Richard T. Jaspers, Janak L. Pathak, Huade Zheng, Lihong Wu · 2026
Read A LECT2-eluting in situ coaxial electrospun nanofiber dressing orchestrates oxidative stress resolution and immune reprogramming for accelerated wound healing by Zhichao Zheng, Jiasheng Mao, Haohui Zhu, Zhihe Fu, Wei Xie, Shaofen Xu, Yan Wang, Shuiqing Yu, Ziyi Liu, Lijing Wang, Richard T. Jaspers, Janak L. Pathak, Huade Zheng, Lihong Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13311918.txt.
Description
Zhichao Zheng and co-authors, in 2026, report a study on a wound dressing spun in place that slowly releases LECT2, a protein tied to inflammation and vessel growth. Chronic wounds stall in a harsh, oxygen-radical-rich setting.
The coaxial fiber dressing pairs two polymer blends in core and shell for steady release. In cell work, LECT2 mopped up reactive oxygen through the NRF2/SOD path, helped vessel growth under stress, and killed staph bacteria, including resistant strains. It also pushed macrophages toward a repair mode. Animal wounds closed faster with better skin regrowth and new vessels, making the dressing a multi-tool candidate.
Catalog record
| CREATOR | Zhichao Zheng, Jiasheng Mao, Haohui Zhu, Zhihe Fu, Wei Xie, Shaofen Xu, Yan Wang, Shuiqing Yu, Ziyi Liu, Lijing Wang, Richard T. Jaspers, Janak L. Pathak, Huade Zheng, Lihong Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67762 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |