Anti-CD20 and -PD-1 antibody effects on proliferation, apoptosis and cell cycle of endometrial cancer cells
Jinqiu Su, Jiayuan Du, Yaojie Yu, Mei Feng, Qiuyue Huang, Bing Liu, He Wang · 2026
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Description
Jinqiu Su and co-authors, in 2026, present a lab study testing two antibody drugs, rituximab and pembrolizumab, against endometrial cancer cells. One targets CD20, the other the PD-1 checkpoint.
Gene data showed both target genes run high in these tumors. Two cancer cell lines were dosed with each drug alone and together, then checked for growth, death, and cycle stage. Each drug slowed growth, raised cell death, and stalled the cycle in a dose-linked way. The pair together suppressed growth more than either alone. The authors see a case for testing the pairing beyond the dish.
Catalog record
| CREATOR | Jinqiu Su, Jiayuan Du, Yaojie Yu, Mei Feng, Qiuyue Huang, Bing Liu, He Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23591 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |