Identification and function of type IV IFN, IFN-υ and its receptor subunits, IFN-υR1 and IL-10RB in chicken Gallus gallus
Shan Zhang, Tian Shun Wei, Chao Wei Zhang, Xiao Yuan Xu, Jing Wei Song, Peng Fei Mu, Bang Xiao, Su Wang, Bo Li, Pin Nie · 2026
Read Identification and function of type IV IFN, IFN-υ and its receptor subunits, IFN-υR1 and IL-10RB in chicken Gallus gallus by Shan Zhang, Tian Shun Wei, Chao Wei Zhang, Xiao Yuan Xu, Jing Wei Song, Peng Fei Mu, Bang Xiao, Su Wang, Bo Li, Pin Nie (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13311837.txt.
Description
Shan Zhang and colleagues report a 2026 study identifying a type IV interferon in chickens, and the two receptor parts it uses. Interferons are signaling proteins that organize antiviral defense. Type IV is a recently recognized family whose role in poultry was unclear. The team located the chicken gene, compared its setting across species, and charted where the interferon and its receptors are expressed. They also tested a lab-made version of the protein.
The chicken protein carries the family's conserved structural marks. It clusters firmly within type IV, apart from types I, II, and III. It appears in many tissues, with higher levels in immune and mucosal organs, and rises after a viral mimic challenge. In cell tests the protein switched on interferon-stimulated genes. It strongly suppressed Tembusu virus replication and softened viral damage. Chickens thus run a working type IV defense worth factoring into poultry antiviral research.
Catalog record
| CREATOR | Shan Zhang, Tian Shun Wei, Chao Wei Zhang, Xiao Yuan Xu, Jing Wei Song, Peng Fei Mu, Bang Xiao, Su Wang, Bo Li, Pin Nie |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |