Elucidating the interaction between pyrazine flavor compounds and coffee proteins: Insights from multiscale structural and molecular dynamics simulations

Xinxin Yu, Zhang Su, Guanghua Xia, Dachuan Zhang, Hehe Li, Wenjiang Dong · 2026

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Description

Xinxin Yu and co-authors study how pyrazine aroma compounds bind coffee proteins in a 2026 article. These compounds give roasted coffee much of its smell, and protein binding shapes how long flavor lasts.

Four pyrazines were compared at two strength levels. Binding strength followed a clear order, with the three-methyl form gripping hardest. Light-based tests showed the compounds dim protein glow by mixed paths and sit near key amino acid sites. Binding clumped the protein and shifted its shape, most strongly for the top binder. Computer models backed the ranking. The results link aroma structure to flavor retention.

Catalog record

CREATORXinxin Yu, Zhang Su, Guanghua Xia, Dachuan Zhang, Hehe Li, Wenjiang Dong
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE59867
LICENSEhttps://creativecommons.org/licenses/by/4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/article/MED/PMC13311791

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