Version upgrades in treatment planning Systems affect clinical application of a multi-Centre knowledge-based planning model
Karen McGoldrick, Colin Hornby, Peter Griffin, Katrina Woodford, Flavio Nelli, Cathy Markham, Tomas Kron, Nick Hardcastle, Vanessa Panettieri · 2026
Read Version upgrades in treatment planning Systems affect clinical application of a multi-Centre knowledge-based planning model by Karen McGoldrick, Colin Hornby, Peter Griffin, Katrina Woodford, Flavio Nelli, Cathy Markham, Tomas Kron, Nick Hardcastle, Vanessa Panettieri (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13311788.txt.
Description
Karen McGoldrick and co-authors ask, in a 2026 study, whether upgrading radiotherapy planning software changes the plans a knowledge-based model produces. Twenty prostate cancer data sets were planned in three versions of the Eclipse system, using a multi-centre RapidPlan model built in the oldest version. Each plan kept identical beam arrangements and settings, and the model was also retrained inside the two newer versions for comparison.
Differences appeared often: target dose measures differed significantly in 10 of 28 comparisons, and organ-at-risk measures in 23 of 56 comparisons. Retrained models improved target coverage and several organ dose measures, while the remaining increases were tiny, at most 1.4 percent in the affected measures. The findings back the vendor's advice that models should be re-extracted and retrained after every software upgrade, so planned doses stay as intended.
Catalog record
| CREATOR | Karen McGoldrick, Colin Hornby, Peter Griffin, Katrina Woodford, Flavio Nelli, Cathy Markham, Tomas Kron, Nick Hardcastle, Vanessa Panettieri |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |