COVID-19 mRNA vaccination and immune-related adverse events in patients with cancer receiving immune checkpoint inhibitors: a target trial emulation study
Po-Huang Chen, Wei-Cheng Chang, Hong-Jie Jhou, Hsin-Yu Chen, Li-Ting Kao, Tina Yi-Jin Hsieh, Ming-Shen Dai, Cho-Hao Lee · 2026
Read COVID-19 mRNA vaccination and immune-related adverse events in patients with cancer receiving immune checkpoint inhibitors: a target trial emulation study by Po-Huang Chen, Wei-Cheng Chang, Hong-Jie Jhou, Hsin-Yu Chen, Li-Ting Kao, Tina Yi-Jin Hsieh, Ming-Shen Dai, Cho-Hao Lee (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13311639.txt.
Description
Po-Huang Chen and colleagues present a 2026 emulation study on whether COVID-19 mRNA shots raise immune side effects in cancer patients on checkpoint drugs. The shots may boost the drugs' power but could also stir more immune harm.
Using a global records network, the team matched 3609 vaccinated patients with 3609 unvaccinated patients starting checkpoint therapy for spread cancer. Vaccination within 100 days before treatment start defined the exposed group. Immune side effects over 36 months formed the main outcome, with severe events, deaths, and ICU stays also tracked. Bias checks used a negative-control eye outcome. Vaccinated patients showed higher overall immune event risk.
Catalog record
| CREATOR | Po-Huang Chen, Wei-Cheng Chang, Hong-Jie Jhou, Hsin-Yu Chen, Li-Ting Kao, Tina Yi-Jin Hsieh, Ming-Shen Dai, Cho-Hao Lee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64377 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |