Compensation for impaired sensing of selenoprotein deficiency by alternative cysteine residues in KEAP1
Miu Sato, Takuya Iijima, Takafumi Suzuki, Masayuki Yamamoto · 2026
Read Compensation for impaired sensing of selenoprotein deficiency by alternative cysteine residues in KEAP1 by Miu Sato, Takuya Iijima, Takafumi Suzuki, Masayuki Yamamoto (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13311275.txt.
Description
Miu Sato and colleagues offer a 2026 mouse study on how the KEAP1 sensor protein spots stress when selenium-based defense proteins fail. Different sulfur sites on KEAP1 may sense different kinds of harm.
Mice lacking the Cys151 site kept their NRF2 defense response and liver health when selenoprotein making was blocked in the liver. Mice lacking the Cys226 and Cys613 sites lost the response and suffered severe liver injury. A drug that works through Cys151 restored defense and improved survival in those mice. The work shows separate sensor sites feed one shared defense path.
Catalog record
| CREATOR | Miu Sato, Takuya Iijima, Takafumi Suzuki, Masayuki Yamamoto |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33885 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |