Diosmin-Capped Silver Nanoparticles Promote Osteogenic Differentiation of Human Periodontal Ligament Stem Cells: Box–Behnken Optimization and in vitro Evaluation
Roxane Abdel Gawad, Shymaa Hatem, Nehal I Rizk, Shereen N Raafat, Dalia E Ali, Riham A El-Shiekh, Doaa H Shakshak · 2026
Read Diosmin-Capped Silver Nanoparticles Promote Osteogenic Differentiation of Human Periodontal Ligament Stem Cells: Box–Behnken Optimization and in vitro Evaluation by Roxane Abdel Gawad, Shymaa Hatem, Nehal I Rizk, Shereen N Raafat, Dalia E Ali, Riham A El-Shiekh, Doaa H Shakshak (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13311220.txt.
Description
Roxane Abdel Gawad and colleagues outline a 2026 lab study that loads diosmin, a plant flavonoid, onto silver nanoparticles to help ligament stem cells form bone. Diosmin dissolves poorly in water, which limits its use.
The particles were made by a green method and tuned with a Box-Behnken design that varied silver, diosmin, and heat levels. Human ligament stem cells were then tested for survival and bone-forming activity using stains, enzyme tests, and gene checks. The tuned particles kept cells alive and raised bone markers. The approach could aid repair of teeth and jaw bone in future work.
Catalog record
| CREATOR | Roxane Abdel Gawad, Shymaa Hatem, Nehal I Rizk, Shereen N Raafat, Dalia E Ali, Riham A El-Shiekh, Doaa H Shakshak |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76173 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |