Whole brain fluorescence imaging in Drosophila reveals spreading depolarization and its initiation, propagation, and resilience dynamics
Allison L. Harris, Grace Crowe, Ella Nelson, Mohammad Al Mokbil, Wolfgang Stein · 2026
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Description
Allison L. Harris and co-authors build whole brain imaging for spreading depolarization in fruit flies in a 2026 study. The wave of nerve shutdown links to migraine, stroke, and brain injury, yet its start and spread rules are hard to watch in large brains. Fly brains allow fast, whole organ views with rich gene tools.
Waves began at many shifting sites across and within flies and spread through the whole nervous system in adults and larvae alike. After one wave, tissue resisted a second wave for a time through a raised threshold that did not depend on shutdown itself. Home balance shifts may explain the pause.
Catalog record
| CREATOR | Allison L. Harris, Grace Crowe, Ella Nelson, Mohammad Al Mokbil, Wolfgang Stein |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 92267 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |